Peter Pan Bus Lines is a long-distance/commuter bus carrier headquartered in Springfield, Massachusetts. It operates in the northeastern United States. As of Fall 2014, Peter Pan operated bus lines in Connecticut, District of Columbia, Delaware, Massachusetts, Maryland, New Hampshire, New Jersey, New York, Pennsylvania and Rhode Island. Over four million passengers per year travel on Peter Pan's bus routes.

The company was founded as Yellow Cab Air Line in Springfield, where the company remains based, and was purchased by Peter Carmen Picknelly in 1933. The Picknelly family still owns the company. The company logo is based on an illustration by Roy Best. Each bus, in addition to a number, is also given a name based on the Peter Pan stories.

Peter Pan was affiliated with Trailways beginning in the 1990s, but ended that affiliation in 2005. In 1999, an alliance was formed with Greyhound Lines, coordinating schedules, marketing, and ticket sales. In August 2017, it was announced that this partnership would cease effective September 27, 2017.